Glucocorticoids redirect naive T cells to the bone marrow in malnourished mice

Abstract Glucocorticoids contribute to the daily migration patterns of T cells in well-nourished organisms and are elevated malnourished. We examined effect malnutrition on cell by comparing adoptively transferred malnourished control lymphoid organs recipients. found that generally entered tissues more efficiently than cells, regardless recipient. Strikingly, bone marrow recipients attracted naïve but not marrow. In contrast, spleens mice similar numbers cells. Further experiments revealed residing express higher levels CCR7 lower CD11a also cell-specific deficiency glucocorticoid receptor mice. Indeed, similarly low percentages deficient were observed mice, indicating expression is required for Overall, we have determined modifies both promote at least effects mediated via receptor. NSF-MRI [DBI- 1920116] NSF-RUI [IOS-1951881]